The correlations between vitamin D receptor FokⅠpolymorphism and type 2 diabetes in postmenopausal women

VernacularTitle:川南地区维生素D受体FokⅠ多态性与绝经后女性2型糖尿病的相关性
Author: Xiaoyan WANG ; Xin LIU ; Yue YU ; Can HUANG ; Longshan ZHANG ; Hongming LIU ; Yu DENG ; Zhuang CHEN ; Feng CHEN
Publication Type:Journal Article
Keywords: Diabetes,type 2; Receptors,calcitriol; Single nucleotide polymorphism; Postmenopausal women
From: The Journal of Practical Medicine 2015;(20):3427-3430
CountryChina
Language:Chinese
Abstract: Objective To study the correlations of VDR FokⅠgene polymorphism with type 2 diabetes in postmenopausal women of Han nationality in south Sichuan. Methods 160 patients with type 2 diabetes (T2DM) and 190 healthy cases were enrolled in the study. The VDR FokⅠgene polymorphisms were detected using RFLP-PCR and DNA sequencing. Results The FF, Ff and ff genotype frequencies were 32.5%, 47.5%and 20% in the T2DM group and 15.8%, 53.7%, 30.5% in the control group, respectively (P < 0.05). The allele frequencies were 56.3%, 43.8% in the T2DM group and 42.6%, 57.4% in the control group, respectively (P < 0.05). The risk of T2DM in the FF genotype people was 2.568 times higher than Ff/ff genotype (adjusted OR = 2.568, 95%CI = 1.246 ~ 5.292, P < 0.05). The levels of 2 h PG and HbA1C in the FF genotype people were significantly higher than those of the Ff/ff genotype people (P<0.05). Conclusions There was an association between the VDR FokⅠgene polymorphism and type 2 diabetes incidence in the postmenopausal women in south Sichuan area.