Research progress on the expression of P-glycoprotein in cerebral injury diseases
- VernacularTitle:P－糖蛋白在脑损伤疾病中表达变化的研究进展
- Author:
Dexiu WANG
;
Yuliang WANG
- Publication Type:Journal Article
- Keywords:
P-glycoprotein;
epilepsy;
cerebral ischemia /reperfusion
- From:
Basic & Clinical Medicine
2015;(10):1397-1400
- CountryChina
- Language:Chinese
-
Abstract:
As an energy dependent membrane transporter, P-GP highly expresses in the organs which have the function of barrier and secretory.In the brain, P-GP mainly expresses in the cerebral vascular endothelial cells of blood brain barrier.In the state of brain injury diseases ( such as epilepsy and cerebral ischemia) , P-GP appears in the hippocampus, cortex and striatum of rat brain.At cellular level, it mainly exists in the cerebral vascular endo-thelial cells and also overexpresses in the neurons and glial cells.
