Expression of serum IGF-1,IGFBP-3 in children with obstructive sleep apnea hyponea syndrome
10.16066/j.1672-7002.2015.10.004
- VernacularTitle:阻塞性睡眠呼吸暂停低通气综合征患儿血清中胰岛素样生长因子-1和胰岛素样生长因子结合蛋白-3的表达
- Author:
Fan LOU
;
Tiesong ZHANG
;
Ruiqing LIU
;
Jing MA
;
Yali GUO
;
Tao LU
- Publication Type:Journal Article
- Keywords:
Sleep Apnea,Obstructive;
Child;
Insulin-Like Growth Factor 1;
Insulin-Like Growth Factor Binding Protein 3
- From:
Chinese Archives of Otolaryngology-Head and Neck Surgery
2015;(10):501-503
- CountryChina
- Language:Chinese
-
Abstract:
[ABSTRACT]OBJECTIVETo analyse the levels of serum IGF-1、IGFBP-3 in children with obstructive sleep apnea hyponea syndrome (OSAHS).METHODS50 children with OSAHS and 10 healthy children were enrolled in this study. According to the respiratory disturbance index (AHI). Serum IGF-1、IGFBP-3 of children were determined and the results were analyze.RESULTSSerum level of IGF-1 had significant statistical differences between severe OSAHS group and controls (t=4.275,P<0.05). Serum level of IGFBP-3 had no significant statistical differences between OSAHS children and controls (P>0.05). Serum IGF-1 of severe OSAHS children was negatively correlated with AHI (r=-0.505,P<0.05). Serum level of IGF-1 in moderate and severe OSAHS children were positively correlated with lowest average blood oxygen saturation (r=0.61, 0.553,P<0.05). Serum level of IGF-1 in OSAHS children had no significant correlation with SWS sleep (P>0.05). Serum level of IGFBP-3 in OSAHS children had no significant correlation with AHI, lowest average blood oxygen saturation and SWS sleep (P>0.05).CONCLUSION Serum levels of IGF-1 in children are more easily affected by OSAHS than serum level of IGFBP-3. Growth retardation of children with OSAHS may be related to the decrease of IGF-1 concentration.
