Interleukin 17 and vascular endothelial growth factor expression and correlation analysis in nasal polyp tissues
10.16066/j.1672-7002.2015.10.010
- VernacularTitle:白细胞介素17与血管内皮生长因子在鼻息肉组织中的表达及相关性分析
- Author:
Nan LIU
;
Da LIU
;
Lingbo LIU
;
Hongying LI
;
Yaning ZHANG
;
Yong ZHAO
;
Weihong ZHENG
;
Yi LIU
- Publication Type:Journal Article
- Keywords:
Interleukin-17;
Vascular Endothelial Growth Factors;
Nasal Polyps;
Immunohistochemistry
- From:
Chinese Archives of Otolaryngology-Head and Neck Surgery
2015;(10):523-525
- CountryChina
- Language:Chinese
-
Abstract:
[ABSTRACT]OBJECTIVETo explore the occurrence and development of nasal polyps by studying the interleukin 17 and vascular endothelial growth factor expression level in nasal polyp tissues.METHODSNasal polyps in 30 patients with chronic sinusitis (with polyps), ethmoid sinus mucosa in 30 patients with chronic sinusitis (without polyps), inferior turbinate mucosa in 10 patients with nasal septum deviation were collected intraoperatively. IL-17 and VEGF expression were detected using immunohistochemistry SP testing, and correlation between them was analysed. RESULTS1. The expression of IL-17 and VEGF in nasal polyps group is significantly higher than that of the other two groups.There was significant difference between each two groups statistically (P<0.01). 2. The expression of IL-17 was positively correlated with VEGF expression in nasal polyps.CONCLUSION1. The expression of IL-17 and VEGF increased in nasal polyp tissues. 2. The expression of IL-17 and VEGFwas positively correlated in nasal polyps , and both of them take part in the occurrence and development of nasal polyps.
