Advances in the non-genetic regulation of PTEN tumour suppressor activity
- VernacularTitle:抑癌基因PTEN非基因调控的研究进展
- Author:
Bowei YIN
;
Xie ZHANG
;
Hong LI
- Publication Type:Journal Article
- Keywords:
PTEN;
tumour suppressor;
PI3K-Akt/PKB pathway;
cancer
- From:
Basic & Clinical Medicine
2015;(10):1414-1418
- CountryChina
- Language:Chinese
-
Abstract:
Mutations and deletions of the tumour suppressor PTEN are frequently involved in the development of cancer.However, PTEN is also tightly controlled by various non-genomic mechanisms,such as the epigenetic silen-cing of PTEN, post-transcriptional regulation by non-coding RNAs and post-translational modification.
