Research progress in the long non-coding RNA ANRIL
- VernacularTitle:长链非编码RNA ANRIL的研究进展
- Author:
Che JIANG
;
Weimin WANG
- Publication Type:Journal Article
- Keywords:
long non-coding RNA;
ANRIL;
CDKN2BAS
- From:
Basic & Clinical Medicine
2015;(10):1419-1423
- CountryChina
- Language:Chinese
-
Abstract:
Long non-coding RNAs are important regulators of gene expression.ANRIL which was coded on the Chr9p21.3 loci participates in the pathogenesis of tumor, coronary artery disease, type 2 diabetes mellitus and oth-er diseases.Multiple ANRIL isoforms are tissue-specific.ANRIL mainly functions through Polycomb proteins, while there are also other downstream targets.The mechanism of each isoform and the downstream pathways are hotspots incurrent researches.
