Curative Effect of Atorvastatin Intensive Treatment on Lipid-Lowering in Patients with Type 2 Diabetes and Its Influence on Vascular Endothelial Function
- VernacularTitle:阿托伐他汀强化治疗2型糖尿病患者的调脂疗效及对血管内皮功能的影响
- Author:
Chen HUA
- Publication Type:Journal Article
- Keywords:
Type 2 diabetes;
Atorvastatin;
Intensive lipid-lowering;
Blood fat;
Vascular endothelial function
- From:
China Pharmacist
2015;(11):1944-1946
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To discuss the curative effect of atorvastatin intensive treatment on lipid-lowering in the patients with type 2 diabetes and its influence on vascular endothelial function. Methods: Totally 74 cases of patients with type 2 diabetes were selected and divided into the intensive group ( n=37 cases) and the ordinary group ( n=37 cases) at random. The patients in the two groups were given routine medical treatment, such like diet adjustment, moderate exercise and drug control etc, and the patients in the inten-sive group were additionally given 40 mg atorvastatin orally, once a day, while the patients in the ordinary group were additionally given 20mg atorvastatin orally, once a day for 12 weeks. The changes of blood fat, von willebrand factor (VWF) of serum vascular endothe-lial function, plasma thrombomodulin ( PTM) and vascular endothelial cadherin ( VEC) levels of the patients before the treatment and in the 12th week after the medical treatment were observed and compared, and the adverse drug reactions ( ADR) were evaluated as well. Results:After the 12-week medical treatment, TC, TG and LDL-C levels of the patients in the two groups were obviously de-clined than those before the treatment, while HDL-C levels were obviously raised than those before the treatment ( P<0. 05 or P<0. 01), and the changes in the intensive group was more notable than those in the ordinary group (P<0. 05). Meanwhile, serum VWF, PTM and VEC levels were obviously declined than those before the treatment (P<0. 05 or P<0. 01), and the declining rate in the intensive group was much higher than that in the ordinary group (P<0. 05). Totally 2 and 4 cases of untoward effect appeared re-spectively in the ordinary group and the intensive group with light symptom, and the incidence of ADR showed no statistical difference between the two groups (P>0. 05). Conclusion:Compared with atorvastatin, atorvastatin intensive treatment in the patients with type 2 diabetes has more favorable lipid-lowering effect, which can effectively reduce serum vWF, PTM and VEC levels to improve and rem-edy vascular endothelial function with high security.
