Clinical implication of histone H2 B monoubiquitination level in primary colonic carcinoma
10.13315/j.cnki.cjcep.2015.10.004
- VernacularTitle:组蛋白H2B 单泛素化在原发性结肠腺癌中的表达及意义
- Author:
Qun YANG
;
Cong LIU
;
Si WANG
- Publication Type:Journal Article
- Keywords:
primary colonic neoplasms;
histone H2B monoubiquitination;
immunohistochemistry
- From:
Chinese Journal of Clinical and Experimental Pathology
2015;(10):1095-1098
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To explore the role of histone H2B monoubiquitination in primary colonic carcinoma and clinicopathological pa-rameters of colonic carcinoma. Methods To detecte the expression of histone H2B monoubiquitination in 116 cases of primary colonic carcinoma and 15 cases of normal colonic mucosal tissue by avidin-biotin-peroxidase complex ( ABC)-immunohistochemistry. Results The level of histone H2B monoubiquitination was significantly reduced in poorly differentiated colonic carcinoma 19. 4% (6/31) compared with that of well-differentiated colonic carcinoma 49. 4%(42/85), moderately differentiated colonic carcinoma 49. 4% (42/85) and normal colonic mucosal tissue 86. 7% (13/15) (P<0. 05). The expression of histone H2B monoubiquitination was closely correlated with tumor differentiation, Dukes stage, TNM stage and lymph node metastasis (P<0. 05), but not depended on sex or age (P>0. 05). Conclusion Histone H2B monoubiquitination is obviously associated with the progression of primary colonic carcinoma. Although its specific mechanism still remains unclear, histone H2B monoubiquitination could be a novel potential molecular marker for early diagnosis, clinic treatment and prognosis evaluation.
