Tuberculosis diagnosis based on Flow Cytometry
10.3969/j.issn.1002-2694.2015.10.014
- VernacularTitle:基于流式细胞术诊断结核感染的研究进展
- Author:
Fan WU
;
Lin SUN
;
Xiaoming ZHANG
;
Xinan JIAO
- Publication Type:Journal Article
- Keywords:
tuberculosis;
diagnosis;
IFN-γ;
flow cytometry
- From:
Chinese Journal of Zoonoses
2015;(10):963-966
- CountryChina
- Language:Chinese
-
Abstract:
Tuberculosis (TB) is an infectious disease endangering people’s health around the world ,and diagnosis and ra‐tional treatment are the key to control TB .However ,currently there is no diagnostic golden standard for latent tuberculosis in‐fection (LTBI) .The tuberculin skin test and IFN‐gamma release analysis are regarded as effective methods for TB diagnosis , which is based on host’s cellular immune response to mycobacterial antigens .But the two methods are not perfect ;neither test can make a clear distinction between latent infection and active TB .Flow Cytometry (FCM ) has been widely used in the field of clinical medicine .In recent years ,substantial advances have been achieved in the fields of TB diagnosis and evaluation of treat‐ment efficacy by using the FCM intracellular cytokine detection technology .In this paper ,we will review the latest progress in tuberculosis diagnosis research by using flow cytometry in recent years .
