Therapeutic effects of arotinolol,propranolol and carvedilol on portal hypertension in cirrhotic rats
10.7652/jdyxb201506003
- VernacularTitle:阿罗洛尔、普萘洛尔和卡维地洛对肝硬化大鼠门脉高压症的疗效比较
- Author:
Xiaoyan WANG
;
Xiaolong WAN
;
Xiaoyan GUO
;
Lei DONG
;
Bin QIN
;
Jing LI
- Publication Type:Journal Article
- Keywords:
arotinolol;
carvedilol;
propranolol;
portal hypertension;
rat
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
2015;(6):730-734
- CountryChina
- Language:Chinese
-
Abstract:
ABSTRACT:Objective To study the effects of arotinolol,propranolol and carvedilol on rat portal hypertension and make a comprehensive evaluation of the three drugs.Methods Portal hypertension was induced with CCl4 in rats.Arotinolol,propranolol,and carvedilol were administered for 2 weeks after the model was stable.Mean arterial pressure (MAP),heart rate (HR)and portal venous pressure (PVP)were measured at intubation;α-SMA expression was measured by immunohistochemistry;Masson staining was used to test collagen fibers area.Results Compared with model group,both arotinolol and carvedilol could significantly reduce PVP level (P <0.001),which was lower than that in propranolol group (P <0.001,P =0.032).Compared with those in model group,both MAP and HR in arotinolol group and carvedilol group were significantly reduced (P <0.05),MAP in carvedilol group was lower than in arotinolol group (P = 0.01 1 ).MAP was obviously decreased in propranolol group compared with model group (P =0.003),but HR had no sighificant difference between the two groups (P =0.143).Only TBIL in arotinolol and propranolol groups reduced significantly compared with model group (P <0.001 ).However,ALT, ALB and TBIL were obviously ameliorated in carvedilol group compared with model group (P <0.001,P <0.001, P =0.045).The expression ofα-SMA and the area of collagen fibers in arotinolol,carvedilol and propranolol groups
significantly declined compared with those in model group (P <0.05 ).Conclusion Arotinolol can significantly reduce cirrhotic rats’ portal pressure,with effects similar to those of carvedilol.The effect of arotinolol in improving liver function is weaker than that of carvedilol,but the side effects on MAP are milder than those of carvedilol.
