Clinical Efficacy of Loratadine Combined with Pidotimod in the Treatment of Children with Recurrent Re-spiratory Tract Infection and Effect on Immune Function
- VernacularTitle:氯雷他定联合匹多莫德对反复呼吸道感染患儿的临床疗效及免疫功能的影响
- Author:
He SHUO
;
Hong YI
- Publication Type:Journal Article
- Keywords:
Loratadine;
Pidotimod;
Repeated respiratory tract infection;
Efficacy;
Immune function
- From:
China Pharmacist
2015;(11):1904-1906
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the clinical efficacy of loratadine combined with pidotimod in the treatment of children with repeat-ed respiratory tract infection and the effect of the combination on immune function. Methods:Totally 78 cases of patients with repeated respiratory tract infection were randomly divided into the observation group ( n=39 ) and the control group ( n =39 ) . Both of the groups were treated with the routine correct treatment, and the control group was treated with pidotimod and the observation group was treated with loratadine combined with pidotimod with the treatment course of 8 weeks. The clinical efficacy, clinical symptoms, signs improvements, changes of immune function markers level and incidence of adverse drug reactions between the two groups were observed and compared. Results:The total effective rate of the observation group was significantly higher than that of the control group ( P<0. 05);the disappearance time of pulmonary rales and cough, fading time of tonsil swelling and fever clearing time of the observation group were significantly shorter than those of the control group(P<0. 05). After the treatment, the levels of IgG, IgM and IgA in both groups were significantly lower than those before the treatment (P <0.05); the levels of CD3 +, CD4 + and CD4 + /CD8 + in both groups were significantly higher than those before the treatment (P<0. 05);the levels of immune indices in the observation group were significantly better than those in the control group(P<0. 05). Comparing with the incidence of adverse drug reactions in the control group, no significant difference was shown in the observation group (P>0. 05). Conclusion:The clinical efficacy of loratadine com-bined with pidotimod in the treatment of children with repeated respiratory tract infection is effective, which can improve the clinical symptom and signs and enhance the immune function of children significantly.
