Expression of KAI1/CD82 and CD44 v6 in human laryngeal squamous cell carcinoma and their clinical significance
10.13315/j.cnki.cjcep.2015.10.012
- VernacularTitle:肿瘤转移抑制基因KAI1/CD82及细胞分子CD44 v6在人喉鳞癌中的表达及意义
- Author:
Jiansong SUN
;
Mingqi ZHOU
- Publication Type:Journal Article
- Keywords:
laryngeal neoplasms;
squamous cell carcinoma;
KAI1/CD82;
CD44v6;
immunohistochemistry
- From:
Chinese Journal of Clinical and Experimental Pathology
2015;(10):1127-1130
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To study the expression of metastasis suppressor gene (KAI1/CD82) and cell adhesion molecules(CD44v6) in human laryngeal squamous cell carcinoma ( LSCC) and its clinical significance, and to investigate their relationship. Methods EnVi-sion immunohistochemistry was used to detect the expression of KAI1/CD82 and CD44v6 protein in 64 cases of LSCC tissues and 15 ca-ses of normal laryngeal mucosa ( NLM) tissues. Results The positive rate of KAI1/CD82 in LSCC tissues ( 37. 50%) was signifi-cantly lower than that of the NLM tissues(86. 67%) (P=0. 031), and the positive rate of CD44v6 in LSCC tissues(75. 00%) was significantly higher than that of the NLM tissues(26. 67%) (P=0. 011). The expression of KAI1/CD82 was associated with clinical stages, grade of tumor differentiation, neck lymph node metastasis ( P<0. 05 ) while not related with age, sex and prognosis ( P>0. 05). And CD44v6 with grade of tumor differentiation, neck lymph node metastasis and prognosis (P<0. 05), but not with age, sex and clinical stages (P>0. 05). In addition, KAI1/CD82 expression was negatively correlated with CD44v6 expression (rs = -0. 504, P=0. 036). Conclusion KAI1/CD82 and CD44v6 are mutually inhibited in the tumorigenesis, progress, invasion and metastasis, and detection of the expression of KAI1/CD82 and CD44v6 may be helpful for judging the biological behaviors of LSCC.
