The expressions of AQP1 and VEGF in hepatitis B associated HCC and the significance

VernacularTitle:水通道蛋白1与血管内皮生长因子在乙肝相关性肝癌中的表达及其意义
Author: Yang YAO ; Jie SU ; Rui XU ; Yun YE ; Li WANG
Publication Type:Journal Article
Keywords: hepatitis B associated hepatocellular carcinoma; AQP1; VEGF
From: The Journal of Practical Medicine 2015;(19):3189-3192
CountryChina
Language:Chinese
Abstract: Objective To examine the expressions of AQP1 and VEGF in human hepatitis B associated hepatocellular c arcinoma and to investigate its relationship with the occurrence and development of hepatocellularcarcinoma. Methods AQP1 and VEGF expressionsin the cancer tissues and AQP1 and VEGF levels in the serum were detected in 62 cases of hepatocellula carcinomaby immunohistochemistry and ELISA , respectively. Results The expressions of AQP1 and VEGF in the liver cancers were significantly higher than in the normal tissues (P<0.01). The higher expression was related to pathologic type,degrees of differentiation and lymph node metastasis, but not related to sex, age and TNM stages. In the serum of liver cancer, the concentrations of AQP1 and VEGF were significantly higher than those in the control group. Conclusion High expressions of AQP1 and VEGF in the patients with liver cancer may be correlated to the occurrence and development of liver cancer. Plasma levels ofAQP1 and VEGF may be more meaningful for the evaluation of clinical prognosis.