Advances in research of the reversal of hepatolenticular degeneration with liver fibrosis by transplantation of bone marrow mesenchymal stem cells
10.3969/j.issn.1006-5725.2015.19.024
- VernacularTitle:骨髓间充质干细胞联合青霉胺治疗肝豆状核变性肝纤维化的效果
- Author:
Dongfeng ZHANG
;
Yushu WANG
;
Junfang TENG
- Publication Type:Journal Article
- Keywords:
Hepatolenticular degeneration;
Liver fibrosis;
Bone marrow stem cells;
Penicillamine
- From:
The Journal of Practical Medicine
2015;(19):3195-3199
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect of bone marrow stem cells (BMSCs) transplantation in the treatment of hepatolenticular degeneration of liver fibrosis. Methods Sixty cases with confirmed hepatolenticular degeneration of liver fibrosis were randomly divided into 3 groups: penicillamine group [40 mg/(kg·d)], BMSCs group and BMSCs + penicillamine group. Autologous BMSCs (2 mL) were injected into vein with normal saline (100 mL). Liver tissue pathology biopsy was inspected and the changes in HA, PCⅢ, LN, CⅣ, TIMP-1 and MMP-1 were observed at 0, 4th, 8th and 12th week during the therapeutic process. Results The level of serum fibrotic markers were reduced in every group , while the changes in BMSCs + penicillamine group were especially obvious (P < 0.05). Conclusion Penicillamine combined with BMSCs was effective in the therapy of hepatolenticular degeneration of liver fibrosis.
