The correlations of FcεRI-βgene polymorphisms with clinical manifestations and prognosis inwheezing infants
10.3969/j.issn.1006-5725.2015.19.030
- VernacularTitle:喘息患儿FcεRI－β基因多态性与临床表现及预后的相关性研究
- Author:
Suhua GUO
;
Ying LIN
;
Liyun LI
;
Xin WANG
;
Qundi DENG
- Publication Type:Journal Article
- Keywords:
Infants;
Wheezing;
FcεRI-β;
Gene polymorphism;
Asthma
- From:
The Journal of Practical Medicine
2015;(19):3213-3215
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlations of FcεRI-βgene polymorphisms with clinical manifestation and prognosis inwheezing infants. Methods One hundred and forty-six wheezing infants were recruited and divided into two groups by FcεRI-βdetection using Fluorescent quantitative PCR: Risk genotype group (n = 41) or normal genotype group (n = 105). The genotype distributions,clinical manifestation and asthma,and morbidity were analyzed and compared between the two groups. Results FcεR1 E237G AG/GG was more serious than FcεR1 AA in wheezing infants. (χ2 = 14.202; P = 0.003). No significant differences were found in AS morbidity between the two groups after two years follow-up (χ2 = 2.25;P = 0.13). Conclusion FcεRI-βgene polymorphisms are strongly related with infantile wheezing. Th risk genotype may be the severity of asthma but may not be the major influencing factor of asthma.
