Evaluation of dexmedetomidine combining with sufentanyl for vein analgesia after laryngeal carcinoma surgery
10.3969/j.issn.1006-5725.2015.19.040
- VernacularTitle:右美托咪定复合舒芬太尼用于喉癌患者术后静脉镇痛效果评价
- Author:
Lan YE
;
Bingyu CHEN
;
Ligang TIAN
;
Yu SHANG
- Publication Type:Journal Article
- Keywords:
Dexmedetomidine;
Sufentanil;
PCIA;
Laryngeal carcinoma surgery
- From:
The Journal of Practical Medicine
2015;(19):3241-3244
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effectiveness and safety of dexmedetomidine combining with sufentanyl in controlling PCIA after laryngeal carcinoma surgery. Methods One hundred laryngeal carcinoma patients (ASAⅠorⅡ) were randomly assigned into 2 groups (n = 50, in each group). Group SF: sufentanil 0.04 mg/(kg·h)+dolasetron 12.5 mg; Group DE: dexmedetomidine 0.1 mg/(kg·h) +sufentani 0.02 mg/(kg· h) +dolasetron 12.5 mg, in which all drugs were dissolved in 100 mL 0.9% normal saline. Parameters: Infusion speed 2 mL/h; PCIA dosage 0.5 mL each time; monitor time: 15 min. PCIA were administrated after anesthesia recovery; BP, HR, SpO2, RR, RPP, pain and sedation score, side effect formation rate at 4、12、24、48 h after surgery were also recorded. Results MAP, RPP and HR in group DE were significant decreased compared with group SF at each time point,(P < 0.05); VAS scores had no significant difference between the two groups(P >0.05); Ramsay calm scores in group DE were significant better than that in group SF at each time point after surgery (P < 0.05); Frequency of nausea,vomiting and chills in group DE were significant lower than those in group SF (P < 0.05). Conclusion Small dose dexmedetomidine combination with sufentanil administration in PCIA after laryngeal carcinoma surgery could acquire satisfied analgesic effect , also could eliminate the patient anxious mood , enhance the security in the perioperative period and improve the patients' satisfaction degree , whichis very suitable for multi mode analgesia acquirement.
