Transcatheter arterial chemoembolization combined with endovascular 125I seed strip implantation for primary hepatocellular carcinoma associated with portal vein tumor thrombus：analysis of curative effect
10.3969/j.issn.1008-794X.2015.09.009
- VernacularTitle:经动脉灌注化疗联合125I粒子条治疗原发性肝癌合并门脉癌栓的疗效分析
- Author:
Linlin WU
;
Zhiping YAN
;
Wen ZHANG
;
Qingxin LIU
;
Xudong QU
;
Lingxiao LIU
;
Xiaolin WANG
;
Jianjun LUO
- Publication Type:Journal Article
- Keywords:
primary hepatocellular carcinoma;
hepatic arterial chemoembolization;
endovascular implantation;
125I seed strip;
portal vein;
extensive tumor thrombus
- From:Journal of Interventional Radiology
2015;(9):776-780
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the curative effect of transcatheter arterial chemoembolization (TACE) combined with endovascular 125I seed strip implantation for the treatment of primary hepatocellular carcinoma (PHC) complicated by extensive portal vein tumor thrombus. Methods The clinical data of 72 patients with PHC complicated by extensive portal vein tumor thrombus were retrospectively analyzed. The patients were divided into group A (n=32) and group B (n=40). TACE combined with endovascular 125I seed strip implantation was performed for the patients of group A, while only TACE was employed for the patients of group B. The changes of portal vein tumor thrombus, the survival time and procedure-related adverse events were recorded. The preoperative and postoperative measured values were compared using paired samples t test, the count data were evaluated by χ2 test, and the survival time was analyzed with Kaplan-Meier method. Results Technical success rate of portal vein 125I seed strip implantation was 100%. No serious procedure-related adverse events occurred. The median survival periods of group A and group B were 210 days and 141 days respectively, the difference between the two groups was statistically significant (P=0.012). Conclusion For the treatment of primary hepatocellular carcinoma complicated by extensive portal vein tumor thrombus, TACE combined with endovascular 125I seed strip implantation can significantly improve the patient’s survival time.
