Physiologic function of SENP1:research progress
10.7644/j.issn.1674-9960.2015.10.018
- VernacularTitle:SENP1的生理功能研究进展
- Author:
Rong WANG
- Publication Type:Journal Article
- Keywords:
SUMO;
SENP1;
tumorigenesis;
immunological regulation;
developmental homeostasis
- From:Military Medical Sciences
2015;(10):805-807
- CountryChina
- Language:Chinese
-
Abstract:
Post-transcriptional regulation of prokaryotes is of pivotal importance to the quality control and stability main -tenance of multiple proteins .The ubiquitin and ubiquitin-like proteins-mediated modifications have widely participated in the manipulation of cell cycle control , subcellular localization and cellular metabolisms .Typical ubiquitin like proteins (UBLs) are ubiquitin,SUMO,Nedd8 and FAT10.Recently, the dynamic regulation mechanisms between sumoylation and de-sumoylation have become the cutting edge in the era of ubiquitin-like modifications.In this review, we briefly summa-rized the entire SUMO-mediated modification systems and the intricate balance regulation .We also discussed the counter acting star molecule SENP1 and its relationship with tumor initiation and progression ,immunological regulation and develop-mental homeostasis .
