Application of Peripheral Blood SEPT9 DNA Methylation Assay for Screening of Colorectal Cancer
10.3969/j.issn.1008-7125.2015.10.011
- VernacularTitle:外周血 SEPT9 DNA 甲基化检测在结直肠癌筛查中的应用
- Author:
Wenhui CHU
;
Kaichun WU
- Publication Type:Journal Article
- Keywords:
Colorectal Neoplasms;
Screening;
SEPT9;
DNA Methylation;
Diagnosis
- From:
Chinese Journal of Gastroenterology
2015;(10):622-624
- CountryChina
- Language:Chinese
-
Abstract:
Colorectal cancer is a malignancy with poor prognosis and high mortality and is caused by multiple factors. Colonoscopy,flexible sigmoidoscopy,guaiac-based fecal occult blood test,immunochemical fecal occult blood test,fecal DNA test,CT colonoscopy and serum carcinoembryonic antigen test are the methods frequently used for screening of colorectal cancer,but they all have certain limitations. Elevation of methylation of SEPT9 is associated with the pathogenesis of colorectal cancer,and detection of the level of methylation of SEPT9 in peripheral blood can be used for screening of colorectal cancer in susceptible population. This article reviewed the application of peripheral blood SEPT9 DNA methylation assay for screening of colorectal cancer.
