Advances in Study on Preventive Efficacy of Non-selective beta-Blockers in Patients with Esophageal Gastric Variceal Bleeding
10.3969/j.issn.1008-7125.2015.10.013
- VernacularTitle:非选择性β受体阻滞剂预防食管胃静脉曲张破裂出血的研究进展
- Author:
Xuhong DUAN
;
Yuzheng ZHUGE
;
Feng ZHANG
- Publication Type:Journal Article
- Keywords:
Liver Cirrhosis;
Esophageal Gastric Variceal Bleeding;
Hepatic Venous Pressure Gradient;
Non-Selective beta-Blockers;
Gene Polymorphism
- From:Chinese Journal of Gastroenterology
2015;(10):629-631
- CountryChina
- Language:Chinese
-
Abstract:
Esophageal gastric variceal bleeding(EGVB)is a serious complication of cirrhotic portal hypertension with high mortality rate. Prevention of EGVB is an important mean to improve the survival of patients. Non-selective beta-blockers(NSBBs)is one of the first-line drugs for primary and secondary prevention of EGVB,however,only about 1 / 3 of cirrhotic patients respond to this treatment when evaluated by hepatic venous pressure gradient( HVPG). This may be related to the genetic polymorphisms of NSBBs’receptors and the metabolic enzymes. This article reviewed the progress in study on therapeutic efficacy of NSBBs and its influencing factors for preventing EGVB in cirrhotic patients.
