Application of 18F-FMISO for tumor hypoxia imaging
10.3760/cma.j.issn.2095-2848.2015.05.018
- VernacularTitle:18F-FMISO在肿瘤乏氧显像中的应用研究进展
- Author:
Zhenzhen WANG
;
Qiao RUAN
;
Xinli XIE
;
Xingmin HAN
- Publication Type:Journal Article
- Keywords:
Nitroimidazoles;
Isotope labeling;
Fluorine radioisotopes;
Cell hypoxia;
Trends
- From:
Chinese Journal of Nuclear Medicine and Molecular Imaging
2015;35(5):410-413
- CountryChina
- Language:Chinese
-
Abstract:
Hypoxia is the combined result of tumor over-growth and vascular structural abnormalities.Hypoxia is related to tumor invasiveness,radioresistance,and chemoresistance.18F-fluoromisoni-dzole (18F-FMISO) can selectively bind to hypoxic tissues of malignant tumors,and is thus useful for imaging of tumor hypoxia in cancer diagnosis and treatment.This review summarizes the state-of-art research of 18F-FMISO in comparison with other hypoxic agents when applied to animals and clinical studies.
