Comparison of various sedative regimens during TACE for hepatocellular carcinoma
10.3760/cma.j.issn.1007-8118.2015.07.006
- VernacularTitle:原发性肝癌患者动脉化疗栓塞术前镇静药物的应用
- Author:
Zhongzhi JIA
;
Kai WANG
;
Shaoqin LI
;
Feng TIAN
;
Jinwei ZHAO
;
Guomin JIANG
- Publication Type:Journal Article
- Keywords:
Hepatocellular carcinoma;
Transcatheter arterial chemoembolization;
Diazepam;
Promethazine
- From:
Chinese Journal of Hepatobiliary Surgery
2015;21(7):454-457
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the efficacy and safety of using various sedative regimens during transcatheter arterial chemoembolization (TACE) for hepatocellular carcinoma (HCC).Methods 156 HCC patients were randomly divided into four groups.The control group (n =30):intramuscular injection of 10 ml saline;The diazepam group (n =42):intramuscular injection of 10 mg of diazepam;The promethazine group (n =42):intramuscular injection of promethazine 25 mg;and The combined group (n =42):intramuscular injection of 10 mg of diazepam and promethazine 25 mg.Results The blood pressure and heart rate of the control group was significantly higher than the other three groups,while the combined group was significantly lower than the diazepam and the promethazine groups.The sedative rating:Grade 0 of the four groups were:30,11,18,0 patients respectively;Grade 1 of the four groups were:0,21,15,24 patients respectively;Grade 2 of the four groups were:0,10,9,18 patients respectively;No patients were in grades 3 and 4.The anxiety score of the control group was significantly higher than the other three groups.There was no significant difference in complications among the four groups.Conclusion Diazepam and/or promethazine could be used effectively and safely during TACE,and they could reduce stress response of HCC patients during TACE,and improved tolerance of TACE.
