Duodenal neuroendocrine carcinoma: a clinical analysis of 9 patients
10.3760/cma.j.issn.1007-8118.2015.08.009
- VernacularTitle:十二指肠神经内分泌癌9例临床分析
- Author:
Tianhao ZHANG
;
Linlin QU
;
Yan GAO
;
Jiexu LI
;
Liangjin SUN
;
Jingyu CAO
- Publication Type:Journal Article
- Keywords:
Duodenum;
Neuroendocrine carcinoma;
Diagnosis;
Treatment
- From:
Chinese Journal of Hepatobiliary Surgery
2015;21(8):544-547
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the clinical manifestations,endoscopic features,pathological features,treatment and prognosis of patients with duodenal neuroendocrine carcinoma (DNEC).Methods The clinical data of 9 patients with duodenal neuroendocrine carcinoma who were admitted to our hospital from December 2006 to December 2014 were retrospectively analyzed.Results There were 6 males and 3 females.The mean age was 61.5 years (range 48 ～75 years).The clinical manifestations were abdominal pain (n =7),jaundice (n =4),melena (n =1) and asymptomatic (n =1).The DNEC was usually solitary in the duodenum.The operations included duodenopancreatectomy (n =5),surgical resection (n =2),subtotal gastrectomy (n =1),and 1 patient was palliated by common bile duct stenting using an endoscopic retrograde cholangio-pancreatographic (ERCP) approach.The patients were followed up for 3 ～ 40 months after operation.For the 5 patients who underwent radical excision 4 were alive.One patient died from liver metastasis.For the 4 patients who underwent palliative therapy,one was alive,two died and one lost to follow-up.Conclusions The clinical manifestations of duodenal neuroendocrine carcinoma were non-specific.Endoscopic,pathologic and immumohisotochemical tests were important in the diagnosis.Surgical resection improved the prognosis of these patients.
