Continuous versus intermittent hemofiltration in patients with severe acute pancreatitis
10.3760/cma.j.issn.1007-8118.2015.07.012
- VernacularTitle:持续性与间断性血液滤过治疗重症急性胰腺炎
- Author:
Yuanchao ZHANG
;
Li YU
;
Shichong LIAO
;
Feng GENG
;
Wei LIU
- Publication Type:Journal Article
- Keywords:
Severe acute pancreatitis;
Continuous veno-venous hemofiltration;
Intermittent hemofiltration
- From:
Chinese Journal of Hepatobiliary Surgery
2015;21(7):478-481
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the therapeutic effects of continuous veno-venous hemofiltration (CVVH) versus repeated intermittent veno-venous hemofiltration (RIVVH) on patients with severe acute pancreatitis (SAP).Methods Fifty-six patients with SAP were randomly divided into the CVVH group (n =28) and the RIVVH group (n =28).The clinical symptoms and signs,the APACHE Ⅱ and MODS scores,the result of biochemistry including amylase and lipase,and the plasma levels of TNF-α,IL-6,IL8 before and after treatment,the duration of mechanical ventilation,boosting drug application time,the length of stay in ICU,the surgical intervention rate and the mortality were compared between the two groups.Results The clinical symptoms improved in the two groups after treatment (P ＜ 0.05).The APACHE Ⅱ and MODS scores were all reduced in the two groups after treatment (P ＜ 0.05).When compared with the RIVVH group,the result of biochemistry including amylase and lipase,and the plasma levels of TNF-α,IL6,IL-8 were significantly decreased (P ＜ 0.05).The duration of mechanical ventilation,the length of stay in ICU and the mortality were also significantly decreased in the CVVH group (P ＜ 0.05).Conclusions CVVH was more efficacious than RIVVH in the treatment of SAP.
