Expression and clinical significance of Shh and Gli1 proteins in esophageal carcinoma
10.3760/cma.j.issn.1008-6315.2015.10.001
- VernacularTitle:食管鳞癌组织中Shh和Gli1的表达及其临床意义
- Author:
Wanyu ZHANG
;
Lin WANG
;
Yuan MI
;
Lei WANG
- Publication Type:Journal Article
- Keywords:
Esophageal squamous cell carcinoma;
Hedgehog signal pathway;
Gli1 transcription factor;
Immunohistochemistry
- From:
Clinical Medicine of China
2015;31(10):865-867
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship between expression of Shh and Gli1 in Hedgehog(Hh) signal pathway and esophageal squamous cell carcinoma (ESCC).Methods Expressions of Shh andGli1 were detected in 64 cases primary tumor tissues and 24 cases normal esophageal mucosa with SP immunohistochemistal method.Results There were significant differences of Shh and Gli1 expressions between esophageal carcinoma and normal mucosa epithelium (67.19％ (43/64) vs.4.17％ (1/24), 60.94％ (39/64) vs.4.17％ (1/24);x2 =27.729,22.689;P＜0.01).There were significant differences of Shh expression between different degrees of differentiation in esophageal squamous cell carcinoma, metastasis of lymph node and different clinical staging group (x2 =3.873, 11.349,6.429;P ＜ 0.05 or P＜ 0.01).The positive expression rate of Gli1 showed significant differences between different degrees of differentiation in esophageal squamous cell carcinoma, metastasis of lymph node and different clinical staging group (x2=12.598, 9.741,26.341;P ＜0.01).There was a positive relationship between Shh and Gli1 expression(r =0.259, P＜0.05).Conclusion Hh signaling pathway is abnormally activated in ESCC, so that Shh and Gli1 play important roles in carcinogenesis and progression ofesophageal carcinoma.The Hh signaling pathway may be a useful target in ESCC.
