Adverse effects of two different dose of methotrexate in pediatric acute lymphoblastic leukemia

VernacularTitle:两种不同大剂量甲氨蝶呤治疗小儿急性淋巴细胞白血病的不良反应
Author: Guli NUR ; Xiying GUO
Publication Type:Journal Article
Keywords: Methotrexate; Childhood; Acute lymphoblastic leukemia; Adverse reactions
From: Clinical Medicine of China 2015;31(10):875-878
CountryChina
Language:Chinese
Abstract: Objective To observe the adverse effects of two different high-dose methotrexate(MTX) in pediatric acute lymphoblastic leukemia.Methods Totally 25 cases acute lymphoblastic leukemia children were grouped according to the risk factor,the low-risk group(13 patients) received MTX 3 g/m2 continuous infusion and high-risk group(12 patients) received MTX 5 g/m2 continuous infusion.Using Calcium Folinate(CF) 36 h after first dose MTX (1/6 total dose) ,then compare the incidence rates and the severity of the MTX of adverse effects.Results Gastrointestinal syptoms, hver damage, mucosal damage were the most common adverse effects after high-dose MTX infusion, the two groups had no significant difference (P ＞ 0.05).Conclusion The incidence rates and the severity of adverse reactions of high dose MTX were related directly with the level and the persistencetime of the plasma concentration.