Analysis of change of serum uric acid, C-reactive protein and fibrinogen levels in patients with acute cerebral infarction
10.3760/cma.j.issn.1008-6315.2015.09.014
- VernacularTitle:急性脑梗死患者血清尿酸、C反应蛋白和纤维蛋白原水平的变化及意义
- Author:
Min ZHANG
;
Hongyi LI
- Publication Type:Journal Article
- Keywords:
Acute cerebral infarction;
Uric acid;
C-reactive protein;
Fibrinogen;
Risk factors
- From:
Clinical Medicine of China
2015;31(9):817-819
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss the clinical significance of change of serum uric acid (UA),C-reactive protein(CRP) and fibrinogen(Fg) levels in patients with acute cerebral infarction.Methods Ninetysix patients with acute cerebral infarction were divided into the mild group (n =52),middle group(n =32) and heavy group(n =12) according to illness degree,and 90 healthy person were selected as the control group.The serum UA,CRP and Fg of all groups were compared.Correlation analysis of serum UA,Fg and CRP in patients with acute cerebral infarction was carried.Results The level of serum UA((423.6±46.5) μmol/L vs.(302.4±28.7) μmol/L,t=4.758,P＜0.05),CRP((15.6±2.3) mg/L vs.(1.9±0.8) mg/L,t =14.547,P＜0.05) and Fg((4.6± 1.4) g/L vs.(3.1 ±0.9) g/L,t =3.936,P＜ 0.05) of acute cerebral infarction group were all obviously higher than that of control group,the differences were statistically significant(P＜0.05).The levels of serum UA((366.2±23.5) μmol/L,(398.4± 32.7) μmol/L and (457.4± 56.2) μmol/L,F =7.646),CRP ((7.4±1.6) mg/L,(14.6±1.9) mg/L and (22.8±4.6) mg/L,F=9.837) and Fg((3.3±1.4) g/L,(3.9 ± 1.5) g/L and (5.2 ± 2.1) g/L,F =5.757) of mild,middle and heavy groups rise with illness degree,differences were all statistically significance(P＜0.05).Correlation analysis showed that serum UA,CRP levels and Fg,CRP were positively correlated (r =0.683,0.564),the differences were statistically significant (P ＜0.05).Conclusion Serum UA,CRP and Fg levels in patients with acute cerebral infarction obviously increase and they can be regarded as to predict risk factors of cerebral infarction.
