Relationship between the C-reactive protein and nonalcoholic fatty liver disease prevalence
10.3760/cma.j.issn.1008-6315.2015.09.013
- VernacularTitle:血清C反应蛋白与非酒精性脂肪性肝病的相关性研究
- Author:
Feng ZHU
;
Laiming WANG
;
Chunpeng JI
;
Zhiliang LIU
;
Chunxiang YANG
;
Zhimei WANG
;
Shouling WU
- Publication Type:Journal Article
- Keywords:
C-reactive protein;
Nonalcoholic fatty liver disease;
Multiple logistic regression
- From:
Clinical Medicine of China
2015;31(9):812-816
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between the C-reactive protein (CRP) and nonalcoholic fatty liver disease (NAFLD) prevalence.Methods In this study,63,486 workers who had participated in the Kailuan health examination from July 2012 to October 2013 and without history of drinking,myocardial infarction,stroke and cancer and without data incomplete were recruited.The observation population was divided into three groups according to the levels of CRP at baseline:group 1 (＜ 1 mg/L),group 2 (1-3 mg/ L) and group 3 (＞3 mg/L).The prevalence of NAFLD among three groups was observed.Multiple logistic regression was used to calculated relationship between the CRP and NAFLD prevalence.Results The prevalence of NAFLD in group 1,group 2 and group 3 were 26.9％,42.1％ and 49.3％,respectively,and the differences were significant (x2=2 192.31,P ＜ 0.01).Logistic model showed that after adjustment for age,gender,waist circumference and other confounders,the association between CRP and NAFLD was strong and the OR value (95％ CI) among the group 1,group 2 and group 3 were 1.00,1.49 (1.42-1.56),1.54 (1.45 -1.64),respectively.Conclusion CRP is independently associated with the nonalcoholic fatty liver disease.
