Application value of cell keratin 7 ,thyroid transcription factor-1,Napsin A,cell keratin5/6,p40 and p63 immunohistochemical stains in lung adenocarcinoma and squamous cell carcinoma
10.3760/cma.j.issn.1008-6315.2015.07.005
- VernacularTitle:细胞角蛋白7、甲状腺转录因子1、新天冬氨酸蛋白酶A、细胞角蛋白5/6、p40、p63在肺腺癌及鳞状细胞癌鉴别诊断中的价值
- Author:
Dan ZHAO
;
Chunling YIN
;
Chongli WANG
;
Chen ZHANG
;
Lili ZHANG
;
Haiqing ZHANG
- Publication Type:Journal Article
- Keywords:
Nonsmall-cell lung cancer;
Cell keratin 7;
Thyroid transcription factor-1;
Napsin A;
Cell keratin 5/6;
p40;
p63;
Immunohistochemistry
- From:
Clinical Medicine of China
2015;31(7):593-596
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the significant immunohistochemical marker to identify lung adenocarcinoma(ADC) and squamous cell carcinoma(SCC).Methods Three hundred and twenty-nine Choose 329 cases of nonsmall-cell lung cancer (NSCLC) were chosen.Analysis of the clinical and pathological features.The expression of cell keratin 7 (CK7),thyroid transcription factor-1 (TTF-1),Napsin A,CK5/6,p40 and p63 were detected by using immunohistochemistry.Results (1) Among 329 specimens,containing 129 cases of resections,195 cases of biopsies and 5 cases of pleural effusion specimens.(2)In these cases,187 cases were classified to be ADC,142 cases were classified to be SCC.(3) CK7,TTF-1,Napsin A,CK5/6,p40,p63 sensitivity were 97.9％,87.2％,81.3％,6.4％,3.7％,18.7％ in ADC groups,and 25.4％,11.3％,0,92.3％,95.1％,98.6％ in SCC groups,and the differences of two groups were significant statistically (x2 =190.665,187.432,214.542,242.003,274.407,206.818;P＜ 0.001).(4) In the 3 IHC of ADC,CK7 had the highest sensitivity,Napsin A had the highest specificity.In the 3 IHC of SCC,p63 had the highest sensitivity,p40 had the highest specificity.Conclusion CK7,TTF-1,Napsin A,CK5/6,p40 and p63 can be a markable panel of immunohistochemistry in the differential diagnosis of NSCLC.
