Significance of thyroid function screening in high-risk pregnant women with gestational diabetes in early pregnancy
10.3760/cma.j.issn.1008-6315.2015.05.026
- VernacularTitle:妊娠期糖尿病高危孕妇妊娠早期甲状腺功能筛查的意义
- Author:
Yingying MU
;
Yuxiu LIU
;
Xia XIU
- Publication Type:Journal Article
- Keywords:
Gestational diabetes;
Thyroid function;
Autoantibodies
- From:
Clinical Medicine of China
2015;31(5):461-463
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the significance of thyroid function screening in high-risk pregnant women with gestational diabetes (GDM) in early pregnancy.Methods A total of 194 cases with GDM were selected as our subjects.The patients were divided into group A(three normal items,a total of 109 cases),group B (one abnormal item,a total of 57 cases) and group C (two abnormal items,a total of 28 cases).The levels of serum anti-thyroglobulin antibody (TGAb),anti-thyroid peroxidase antibody (TPOAb),serum three triiodothyronine(TT3),thyroxine (TT4),free three triiodothyronine (FT3),free thyroxine (FT4) and thyroidstimulating hormone (TSH) were screened.Results TSH levels in group A was (1.45 ± 0.43) mU/L,significantly lower than in group B and group C((1.77±0.53),(1.89±0.74) mU/L).FT4 levels in group A was (11.62±0.98) nmol/L,significantly higher in group B and group C((10.23±0.75),(9.87±0.88) nmol/L)).Proportion of TPOAb,TGAb positive in group A were 9.17%(10/109) and 21.05%(12/57),significantly lower than that of group B and group C((28.57%(8/28) and 3.67%(4/109),7.02%(5/57) and 17.86%(5/28)).And the differences were significant (P< 0.05).And TPOAb + TGAb in group A was 0.92%(1/109),significantly lower than that of group B and group C(7.02% (4/57),17.86% (5/28);P <0.05).Conclusion The importance of screening thyroid function in early pregnancy in women at high risk for gestational diabetes is worthy of clinical promotion.