Effect of Danhong injection combined with atorvastatin treatment on hs-CRP and hemodynamics of patients with unstable anginapectoris
10.3760/cma.j.issn.1008-6315.2015.05.009
- VernacularTitle:辛伐他汀联合丹红注射液对不稳定型心绞痛患者血清超敏C反应蛋白及血流变的影响
- Author:
Huibin HAO
- Publication Type:Journal Article
- Keywords:
Simvastatin;
Danhong injection;
Unstable anginapectoris;
High-sensitivity C-reactive protein
- From:
Clinical Medicine of China
2015;31(5):410-413
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate effect of Danhong injection combined with atorvastatin treatment of patients with unstable anginapectoris.Methods Ninety patients with unstable anginapectoris from Mar.2010to Dec.2013 in the First People's Hospital were selected and randomly grouped as control group(n=40) and atorvastatin-Danhong injection group(n =50).All patients in two groups were treated with routine therapy,and patients in the atorvastatin-Danhong injection group were also treated with atorvastatin at dose of 20 mg per day for 15 days and Danhong injection at dose of 30 ml in 250 ml physiological saline per day for 15 days.The level of high-sensitivity C-reactive protdn(hs-CRP) in serum and the haemodynamics of two groups during before and post-treatment were measured and analyzed.Results The effective rate of atorvastatin-Danhong injection group was 84.0％ (42/50),higher than that in control group (70.0％ (28/40),x2 =5.738,P =0.039).The level of hs-CRP in two groups at after treatment were (7.6±2.1) and (3.6±1.7) mg/L,lower than those at pretreatment((1 8.6±4.7) mg/L,(19.2±4.2) mg/L),and the differences were significant (t =8.644,7.848;P =0.004,0.007).Compared with control group after treatment,the level of hs-CRP in atorvastatin-Danhong injection group decreased rapidly (t =6.384,P =0.009).Compared with pre-treatment,the low cut blood viscosity(LCBV),high shearrate blood viscosity(HSBV),plasma viscosity and red cell assembling index in two groups were decreased remarkably(P＜0.05).Compared with control group at post-treatment,the LCBV,HSBV,plasma viscosity and red cell assembling index in atorvastatin-Danhong injection group were significantly declined (t=5.142,4.672,5.738,5.354;P＜0.05).Conclusion Danhong injection combine with atorvastatin improves the haemodynamics in patients with unstable anginapectoris and induce the inflammatory reaction,and it has the better the effects.
