Expression of caveolin-1 and PY14caveolin-1 and its clinical significance in esophageal squamous cell carcinoma
10.3760/cma.j.issn.1008-6315.2015.11.001
- VernacularTitle:小窝蛋白1及其磷酸化在食管鳞癌组织中的表达及其临床意义
- Author:
Jing YU
;
Shengxin TANG
;
Ruinuan WU
;
Zhaohui LIU
;
Xiaoman CAI
;
Guanghua GUO
;
Suzuan CHEN
- Publication Type:Journal Article
- Keywords:
Esophageal squamous cell carcinoma;
Caveolin-1;
PY14caveolin-1
- From:
Clinical Medicine of China
2015;31(11):961-963
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the expression of caveolin-1 and PY14caveolin-1 in different esophageal tissues,and study the relationships between the expressions of caveolin-1 and PY14caveolin-1 with the occurrence and development of esophageal squamous cell carcinoma.Methods The fresh surgical specimens in 60 patients with esophageal squamous cell carcinoma were collected and Western blotting were used to analyze and detect the expressions of caveolin-1 and PY14caveolin-1 in esophageal squamous cell carcinoma,adjacent esophageal tissues and normal esophageal tissues.The expression of cav-1 and PY14caveolin-1 with esophageal squamous cell carcinoma were analyzed.Results The expressions of caveolin-1 and PY14caveolin-1 in esophageal squamous cell carcinoma were much higher than that in adjacent tissues and normal esophageal tissues,and the difference between them was statistically significant(P＜0.05).Conclusion The expression of caveolin-1 and PY14caveolin-1 in esophageal squamous cell carcinoma, adjacent esophageal tissues and normal esophageal tissues decreases successively,it suggests the caveolin-1 and PY14caveolin-1 may be the key of the occurrence and development of esophageal cancer cells and they could be involved in the migration and invasion of esophageal cancer.
