Antiepileptic drug valproic acid and topiramate effects on body weight and plasma leptin levels:a meta analysis
10.3760/cma.j.issn.1674-6554.2015.08.026
- VernacularTitle:丙戊酸和托吡酯对体质量和血浆瘦素水平影响的Meta分析
- Author:
Lili LI
;
Tian TIAN
;
Dongjing ZHAO
;
Danfeng XU
;
Hang NI
- Publication Type:Journal Article
- Keywords:
Epilepsy;
Valproic acid;
Topiramate;
BMI;
Leptin
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2015;24(8):764-768
- CountryChina
- Language:Chinese
-
Abstract:
Objective To systematic evaluation the antiepileptic drug valproic acid and topiramate effects on body weight and plasma leptin levels.Methods By searching the Cochrane Library,PubMed,EMBASE,CNKI,VIP Chinese Scientific Journals Database and Articles Database (from building a database to August 1,2014),qualified RCT was chosen from those articles according to inclusion and exclusion criterias and evaluated their quality.Then the meta-analysis was performed by Rev Man 5.3.Results (1) A total of 70 documents retrieved for the evaluation,12 of the literatures could be incorporated into the Meta-analysis,including a total of 634 participants,9 literatures using valproate to treat epilepsy,4 literatures used topiramate.(2)Meta-analysis:compared with other drugs,valproic acid treatment increased body mass index and leptin level in patients with epilepsy,BMI combined MD=0.88(95％ CI:0.45-1.31),leptin level in the combined MD=0.58(95％ CI:0.07-1.09);compared with other drugs,topiramate affect body mass index and leptin level in patients with epilepsy had no statical difference,BMI combined MD=-0.02 (95％ CI:-0.62-0.58),leptin levels in the combined MD =-0.05(95％ CI:-0.31-0.20).Conclusion Antiepileptic drug valproic acid may increase patients' BMI and serum leptin levels,yet topiramate in do not have influence in patients BMI and serum leptin levels;more basic and clinical researches are needed to explore serum leptin levels and the exact therapy mechanisms of antiepileptic drugs for clinicians to select antiepileptic drugs.
