Relationship between memory impairment and N-methyl-D-aspartate receptor 2B expression in alcohol dependence patients

VernacularTitle:酒依赖患者记忆损害与NMDA受体2B亚基表达的关系研究
Author: Yahui XU ; Chuansheng WANG ; Sanqiang ZHANG ; Tieqiao LIU ; Wei HAO ; Ruiling ZHANG
Publication Type:Journal Article
Keywords: Alcohol dependence; Memory impairment; N-methyl-D-aspartate receptor 2B
From: Chinese Journal of Behavioral Medicine and Brain Science 2015;24(9):805-807
CountryChina
Language:Chinese
Abstract: Objective To explore the characteristic of memory impairment and its relationship with Nmethyl-D-aspartate receptor 2B (NR2B) expression in alcohol dependence patients,in order to provide an unprecedented view of alcohol-associated memory impairment therapy.Methods Participants (n=67) included 35 alcohol dependence patients and 32 matched healthy controls.Wechsler memory scale (WMS) was used to access the memory.The expression levels of NR2B were detected with quantitative reverse transcription-polymerase chain reaction (qRT-PCR).Results Compared with the memory quotient(MQ) of controls(69.45±8.96),that of alcohol dependence patients(50.59±8.64) significantly decreased (t=-6.08,P＜0.01).Compared with the NR2B expression level of controls (1.00-0.00),that of alcohol dependence patients (3.52 ± 1.17) significantly increased (t =9.67,P＜0.01).MQ was negatively correlated with the levels of NR2B expression (r=-0.44,P＜0.05).Conclusion Alcohol dependence patients suffer memory impairment detected by WMS,and modulate NR2B expression may improve the memory.