The role of Orexin in pathogenesisepilepsy and treatment of epilepsy

VernacularTitle:Orexin在癫痫发病及治疗中的作用
Author: Weixia YANG ; Jun ZHAO ; Fengjing SHI ; Lin KAN ; Weifang YANG
Publication Type:Journal Article
Keywords: Epilepsy; Orexin; Orexin receptor
From: Chinese Journal of Behavioral Medicine and Brain Science 2015;24(7):669-671
CountryChina
Language:Chinese
Abstract: Objective To explore the role of Orexin in pathogenesisepilepsy and treatment of epilepsy based on the literatures published from 1998 to 2014 at home and abroad.Methods Searched the literatures from the online database including Pubmed,CNKI and Wanfang Datebases in July 2014.The words Orexin,epilepsy,Orexin receptor,epilepsy treatment were used as search terms.Analyze the effect Orexin and its receptors in the occurrence,development and treatment of epilepsy.Results 102 related literatures were retrieved and 30 were adopted into analysis.It was showed Orexin is a kind of excitatory neuropeptides and it can increase the excitability of cerebral cortex.Epilepsy can be induced bv excessive expression of Orexin.Conclusion Excessive expression of Orexin can cause epileptic seizure.Inhibiting the excessive activation of Orexin neurons is of important to control seiznres in clinical practices.