Clinical Characteristics and Prognosis in Patients With Mid-ventricular Obstructive Hypertrophic Cardiomyopathy
10.3969/j.issn.1000-3614.2015.11.006
- VernacularTitle:左心室中部肥厚型梗阻性心肌病的临床特点及预后
- Author:
Shuoyan AN
;
Chaomei FAN
;
Shihua ZHAO
;
Yueqin TIAN
;
Yanling LIU
;
Fujian DUAN
;
Zhimin WANG
;
Hongyue WANG
;
Chi CAI
;
Lirong YAN
;
Xiying GUO
;
Yinjian YANG
;
Yishi LI
- Publication Type:Journal Article
- Keywords:
Mid-ventricular;
Hypertrophy;
Obstruction;
Apical aneurysm
- From:
Chinese Circulation Journal
2015;(11):1053-1057
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To describe the clinical characteristics with long-term prognosis in patients with mid-ventricular obstructive hypertrophic cardiomyopathy (MVOHCM).
Methods: A total of 66 MVOHCM patients treated in our hospital were retrospectively studied for their morbidity, clinical characteristics and mortality. The cumulative survival rate was calculated by Kaplan-Meier method; the risk factors for cardiac death and cardiovascular events were analyzed by uni- and multivariate Cox proportional hazard model.
Results: There were 66 (2.74%) patients suffering from MVOHCM among 2413 patients of hypertrophic cardiomyopathy and the average diagnostic age was (40.16 ± 14.64) years. With (7.30 ± 6.25) years of follow-up study, the cardiovascular mortality was 13.6% and unexplained syncope (HR=13.37, 95% CI: 1.65-114.46, P=0.015) was the independent predictor for cardiovascular death. There were 45.45% (30/66) patients experienced at least 1 time of cardiovascular event and the most frequent one was non-sustained ventricular tachycardia (NSVT); 19.70% (13/66) of patients combined with apical aneurysms, and they were more inclined to experience NSVT.
Conclusion: MVOHCM patients usually have unfavorable prognosis with the higher incidence of cardiovascular events, some patients may develop apical aneurysm. The early diagnosis of MVOHCM is important for appropriate treatment.
