Clinical and pathological analysis of microscopic thymoma and nodular hyperplasia of the thymic epithelium

VernacularTitle:微小胸腺瘤和胸腺上皮结节状增生的临床病理分析
Author: Xiumin QI ; Yan XIAO ; Qi DING ; Rongrong ZHANG
Publication Type:Journal Article
Keywords: Microscopic thymoma; Myasthenia gravis; Thymus
From: Chinese Journal of Endocrine Surgery 2015;9(4):312-315
CountryChina
Language:Chinese
Abstract: Objective To investigate the clinical and pathological features of microscopic thymoma(MT).Methods The histopathological features of 12 cases of MT were observed by histopathologic and immunohistochemical methods.The pathological morphology,diagnosis,and differential diagnosis were discussed combined with literature.Results 6 cases of MT were accompanied by myasthenia gravis(MG) symptoms.Focal hyperplastic thymic epithelial islands were accompanied by large tracts of mature adipose tissue in 12 cases of MTs,and immunohistochemistry showed CK positive.Cyst formation was found in 5 cases,lymphoid hyperplasia in 7 cases,and vascular proliferation in 5 cases.Conclusions MG may be the clinical manifestation of MT.MT can occur in thymic cortex,medulla and cortex and medulla junction.Since the tumor is small and the lesions are multiple,it can not be found by X-ray or CT examination.Diagnosis depends on histopathological examination.Correct understanding of the clinical and pathological features of MT has guiding significance on the treatment and prognosis judgment of MT.Thymic resection was recommended for MG patients either with or without thymoma.