Preoperative oral carbohydrate alleviates postoperative insulin resistance and inflammatory reaction
10.3760/cma.j.issn.1674-6090.2015.04.012
- VernacularTitle:术前口服葡萄糖溶液对胃肠术后胰岛素抵抗及炎症反应的影响
- Author:
Zhanjiang CAO
;
Jianchun YU
;
Weiming KANG
;
Zhiqiang MA
;
Xin YE
;
Qingbin MENG
;
Shubo TIAN
- Publication Type:Journal Article
- Keywords:
Preoperative carbohydrate;
Insulin resistance;
Inflammatory reaction
- From:
Chinese Journal of Endocrine Surgery
2015;9(4):305-308
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of preoperative oral administration of carbohydrate on blood glucose,insulin resistance(IR) and inflammatory reaction after gastrointestinal operation.Methods 48 patients receiving gastrointestinal operation were randomly divided into the study group(n =23)and the control group(n =25).Patients in the study group were orally given 25％ glucose solution 300 ml 3 hours before operation.Before anesthesia induction,gastric contents were aspirated through nasogastric tube to examine its volume and pH.Serum high sensitivity C-reactive protein(hsCRP),fasting blood glucose,insulin level and homeostasis model assessment-insulin resistance(HOMA-IR) were detected before operation and on the first morning after operation between the two groups.Results No anesthesia or operation related complications occurred in either groups.Patients had similar gastric contents volume and the PH value of gastric contents.There was no significant difference in serum hsCRP,fasting blood glucose and HOMA-IR between the two groups before operation.But on the first day,fasting blood glucose,HOMA-IR and hsCRP were significantly lower in the study group than in the control group(6.51 ±1.15 vs 7.49 ±0.57 mmol/L,P =0.038;4.34 ± 1.60 vs 6.09 ±2.81,P =0.043;40.45 ± 27.02 vs 80.02 ± 38.98 mg/L,P =0.03).Conclusion Preoperative oral administration of carbohydrate can obviously lower the postoperative blood glucose level and insulin resistance and alleviate postoperative inflammatory reaction.
