O-GlcNAc Modification: Friend or Foe in Diabetic Cardiovascular Disease.
10.4093/kdj.2010.34.4.211
- Author:
Udayakumar KARUNAKARAN
1
;
Nam Ho JEOUNG
Author Information
1. Department of Medical Sciences, Kyungpook National University School of Medicine, Daegu, Korea.
- Publication Type:Review
- Keywords:
Acetylglucosaminidase;
Diabetes mellitus, type 2;
Glycosyltransferase;
Vascular diseases
- MeSH:
Acetylglucosaminidase;
Cardiovascular Diseases;
Cardiovascular System;
Cell Survival;
Cytosol;
Diabetes Mellitus, Type 2;
DNA;
Friends;
Glucose;
Humans;
Insulin Resistance;
Nuclear Proteins;
Phosphorylation;
Protein Processing, Post-Translational;
Proteins;
Serine;
Threonine;
Transcription Factors;
Vascular Diseases
- From:Korean Diabetes Journal
2010;34(4):211-219
- CountryRepublic of Korea
- Language:English
-
Abstract:
O-Linked beta-N-acetyl glucosaminylation (O-GlcNAcylation) is a dynamic post-translational modification that occurs on serine and threonine residues of cytosolic and nuclear proteins in all cell types, including those involved in the cardiovascular system. O-GlcNAcylation is thought to act in a manner analogous to protein phosphorylation. O-GlcNAcylation rapidly cycles on/off proteins in a time scale similar to that for phosphorylation/dephosphorylation of proteins. Several studies indicate that O-GlcNAc might induce nuclear localization of some transcription factors and may affect their DNA binding activities. However, at the cellular level, it has been shown that O-GlcNAc levels increase in response to stress and augmentation of this response suppresses cell survival. Increased levels of O-GlcNAc have been implicated as a pathogenic contributor to glucose toxicity and insulin resistance, which are major hallmarks of type 2 diabetes and diabetes-related cardiovascular complications. Thus, O-GlcNAc and its metabolic functions are not yet well-understood; focusing on the role of O-GlcNAc in the cardiovascular system is a viable target for biomedical investigation. In this review, we summarize our current understanding of the role of O-GlcNAc on the regulation of cell function and survival in the cardiovascular system.
