Research advances on the significance of FOXA1 in breast cancer
10.3760/cma.j.issn.1673-422X.2015.09.017
- VernacularTitle:叉头盒蛋白A1在乳腺癌的作用
- Author:
Xiangrong LUO
;
Xiaolong WEI
;
Weiling CHEN
;
Guojun ZHANG
- Publication Type:Journal Article
- Keywords:
Breast neoplasms;
Stromal cells;
Forkhead box A1
- From:
Journal of International Oncology
2015;42(9):702-705
- CountryChina
- Language:Chinese
-
Abstract:
Forkhead box A1 (FOXA1) is expressed in various organs,including breast,liver,pancreas,bladder,prostate,colon,ovary,lung and esophagus.The FOXA1 expression is associated with the growth and carcinogenesis of these organs.It is recently demonstrated FOXA1 plays a significant role in different biological processes including cell proliferation,differentiation,devolopment,carcinogenesis and the process of epithelial-mesenchymal transition (EMT) etc.Its expression is positively correlated with ER and PR expression,and it is demonstrate to be one of the most important favorate prognostic factors of breast cancer.
