Functional mechanism of the mutual regulation between long non-coding RNAs and other epigenetic mechanisms in cancer
10.3760/cma.j.issn.1673-422X.2015.09.008
- VernacularTitle:长非编码RNA与其他表观遗传机制的相互调控在肿瘤中的作用机制
- Author:
Yini DANG
;
Guoxin ZHANG
- Publication Type:Journal Article
- Keywords:
RNA;
Epigenesis,genetic;
Neoplasms
- From:
Journal of International Oncology
2015;42(9):671-674
- CountryChina
- Language:Chinese
-
Abstract:
Abnormal expressions of long non-coding RNAs (LncRNAs) are associated with a variety of tumors.Recent studies show that lncRNA can regulate other epigenetic processes such as DNA methylation,histone modifications,chromatin remodeling and miRNA through various ways;on the other side,other epigenetic processes can influence the expression of lncRNA.The mutual regulation of them paly important roles in the occurrence and development of malignant tumors.The better understanding of the crosstalk between lncRNA and epigenetic modulation will contribute to clearly clarify the mechanism of tumor,which provides a theoretical basis for the anti-cancer therapies targeting lncRNAs.
