Value of body mass index predicting efficacy of neoadjuvant chemotherapy and prognostic in breast cancer
10.3760/cma.j.issn.1673-4203.2015.09.013
- VernacularTitle:体重指数预测乳腺癌新辅助化疗疗效和预后的价值
- Author:
Yongnan WANG
;
Jian WAN
;
Anqin ZHANG
;
Wenping LI
;
Zhongyang CHEN
;
Yizhong LUO
- Publication Type:Journal Article
- Keywords:
Body mass index;
Breast neoplasms;
Chemotherapy
- From:
International Journal of Surgery
2015;42(9):619-623
- CountryChina
- Language:Chinese
-
Abstract:
Objective Resarech on the value of body mass index (BMI) predicting efficacy of neoadjuvant chemotherapy and prognostic in breast cancer.Methods Clinical data of 99 patients who received neoadjuvant chemotherapy Ⅱ B-Ⅲ C stage breast cancer patients was collected between January 2007 and December 2013 in Women and Children Hospital of Guangdong Province.Anaslysing the relation of BMI and efficacy of neoadjuvant chemotherapy and prognosis.Results In the study, Clinaical complete ressiom was 12.1％ (12/99), partal ressiom was 68.7％ (68/99), stable disease or disease progression was 19.2％ (19/99), respone rate was 80.8％ (80/99), pathlogic complete ression was 9.1％ (9/99).BMI was significantly associated with response rate(P =0.039), but not with pathlogic complete ression (P =0.454).Univariate and multivariate analysis showed that BMI was not significantly associated with disease free survival and overall survival(P ＞ 0.05).Conclusions BMI was significantly associated with response rate, overweight or obese patients would prodict poorly efficacy of neoadjuvant chemotherapy.The relationg of BMI and prognosis of breast cancer who accepted neoadjuvant chemotherapy is not clear, for further study.
