Application of precision medicine in non-small cell lung cancer
10.3760/cma.j.issn.1673-4181.2015.04.014
- VernacularTitle:精准医疗在非小细胞肺癌中的应用
- Author:
Pengfei LIU
;
Huilai ZHANG
- Publication Type:Journal Article
- Keywords:
Non-small cell lung cancer;
Precision medicine;
Epidermal growth factor receptor;
Kirsten rat sarcoma viral oncogene homolog;
Tumor protein 53
- From:
International Journal of Biomedical Engineering
2015;38(4):247-252
- CountryChina
- Language:Chinese
-
Abstract:
Lung cancer, with growing morbidity and mortality worldwide, is one of the most malignant tumors, representing a significant threat to human health and life.The application of next-generation genomic technologies has offered a more comprehensive look at the mutational landscape across the different subtypes of nonsmall cell lung cancer (NSCLC).A number of recurrent mutations such as TP53, KRAS, and epidermal growth factor receptor (EGFR) have been identified in NSCLC.While targeted therapeutic successes have been demonstrated in the therapeutic targeting of EGFR and ALK, the majority of NSCLC tumors do not harbor these genomic events.This review looks at the current treatment paradigms for lung adenocarcinomas (LAC) and squamous cell carcinomas, examining genomic aberrations that dictate therapy selection, as well as novel therapeutic strategies for tumors harboring mutations in KRAS and TP53 which, to date, have been considered undruggable.A more thorough understanding of the molecular alterations that govern NSCLC tumorigenesis, aided by next-generation sequencing, will lead to targeted therapeutic options expected to dramatically reduce the high mortality observed in lung cancer.
