Explore chronic myelogenous leukemia related molecular complexes biological pathways based on the protein interaction network
10.3760/cma.j.issn.1009-9921.2015.08.011
- VernacularTitle:基于蛋白质相互作用网络探索慢性粒细胞白血病相关分子复合物生物学通路
- Author:
Wenjing TENG
;
Chao ZHOU
;
Changgang SUN
;
Gongxi LIU
;
Jing YANG
;
Youjie LI
;
Zewang LIU
- Publication Type:Journal Article
- Keywords:
Leukemia,myeloid,chronic;
Proteomics;
Online Mendelian Inheritance in Man database;
Molecular complexes;
Pathway
- From:
Journal of Leukemia & Lymphoma
2015;24(8):487-492
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study on chronic myelogenous leukemia on the basis of protein interaction network to further explore its development mechanism.Methods Chronic myelogenous leukemia-related genes were screened from Online Mendelian Inheritance in Man database (OMIM) of genetic.After text mining by Cytoscape software and Agilent Literature Search,the protein interaction networks of chronic myelogenous leukemia were established.Then the molecular complexes contained in the network were analyzed by Clusterviz plug.The biological pathways of molecular complexes were enriched based on DAVID.Results There were 79 chronic myelogenous leukemia genes in OMIM.The protein-protein interaction network of chronic myelogenous leukemia contained 638 nodes,1 830 edges and maybe 5 molecular complexes.Conclusions Pathways underlying complexes 1 are involved in cytokines and inflammation,cytokines-receptor binding,cytokine receptor signaling.Complexes 3 has relation to complex biological behavior of the tumors and other broad relevance,which can provide the bioinformatic foundation for further understanding the development mechanisms of chronic myelogenous leukemia.
