Neutrophil to lymphocyte ratio and its relationship with the chemotherapy effect and the prognosis in patients with diffuse large B-cell lymphoma
10.3760/cma.j.issn.1009-9921.2015.08.004
- VernacularTitle:弥漫大B细胞淋巴瘤患者中性粒细胞/淋巴细胞比值与疗效及预后的关系
- Author:
Ming ZHU
;
Yanli LI
;
Zhitao WANG
;
Qianshan TAO
;
Zhimin ZHAI
- Publication Type:Journal Article
- Keywords:
Lymphoma,large B-cell,diffuse;
Neutrophil to lymphocyte ratio;
Complete response;
Prognosis
- From:
Journal of Leukemia & Lymphoma
2015;24(8):460-463
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the neutrophil to lymphocyte ratio (NLR) and its relationship with the effect of chemotherapy and prognosis in patients with diffuse large B-cell lymphoma (DLBCL).Methods The clinicopathological characteristics and outcome of 51 patients with DLBCL diagnosed by pathological biopsy and immunohistochemistry who received CHOP or R-CHOP regimen were collected and reviewed.According to the median of NLR,the patients were divided into low NLR group (NLR≤2.32) and high NLR group (NLR＞2.32).The prognostic influence of the NLR on overall survival (OS) was studied by Kaplan-Meier method and Log-rank test.To evaluate the independent prognostic relevance of NLR,univariate and multivariate Cox regression models were applied.Results The complete response (CR) rates of the low and high NLR groups were 71.4 ％ (20/28) and 39.1％ (9/23),respectively (P =0.02).The OS in the low NLR group was significantly better than that in the high NLR group (1,2 and 3-year OSs were 96.4 ％,90.4 ％ and 72.3 ％ vs 63.9 ％,52.7 ％ and 42.2 ％,respectively,P =0.009).Univariate and multivariate Cox regression models analysis showed that NLR ＞ 2.32 was an independent prognostic factor (P =0.016).Conclusion An elevated NLR before treatment indicates the poor effect of chemotherapy and prognosis of patients.NLR is an independent prognostic factor for DLBCL.
