Research progress on role of immuno-inflammatory response in pulmonary artery hypertension
10.3969/j.issn.1001-1978.2015.11.001
- VernacularTitle:免疫炎症反应在肺动脉高压中作用的研究进展
- Author:
Huifang ZHANG
;
Lianhua FANG
;
Guanhua DU
- Publication Type:Journal Article
- Keywords:
pulmonary arterial hypertension;
immuno-inflamma-tory response;
Rho-kinase;
BMPR2;
drug;
drug target
- From:
Chinese Pharmacological Bulletin
2015;(11):1481-1484
- CountryChina
- Language:Chinese
-
Abstract:
Abstrcat:Pulmonary artery hypertension ( PAH) is a cardiopul-monary disease with extensive obliterative changes in the small to midsized pulmonary arterioles. This review summarizes the al-tered inflammation and immune processes underlying the devel-opment of PAH, and discusses inflammatory factors, immune cells, Rho kinase and gene implicated in PAH. Preclinical stud-ies have provided the basis for abnormal immune response in ani-mal models of the PAH, and this paper, based on inflammatory/immune response mechanisms, proposes PAH potential therapeu-tic targets.
