Advance in targeted immunotherapy for hematological malignancies based on immunosuppressive receptors
10.3760/cma.j.issn.1009-9921.2015.08.001
- VernacularTitle:基于免疫抑制性受体的血液肿瘤靶向免疫治疗研究
- Author:
Shaohua CHEN
;
Xianfeng ZHA
;
Yangqiu LI
- Publication Type:Journal Article
- Keywords:
Hematological malignancies;
PD-1;
CTLA-4;
PD-L1;
Molecular targeted therapy
- From:
Journal of Leukemia & Lymphoma
2015;24(8):449-452
- CountryChina
- Language:Chinese
-
Abstract:
T cell immune deficiency results in inefficient anti-tumor immune response in most patients with hematological malignancies,thereby tumor cells escaping the attack of host immune system,that is the immune escape of tumor cells.Recently,new insights regard to the CD8+ T cell exhaustion which is one of the most important mechanisms of tumor immune suppression.The CD8 + T cell exhaustion is mediated by abnormal expression of T-cell immunosuppressive receptors such as PD-1 and CTLA-4.Blocking these molecules may restore the partial or all functions of T cells.This article reviewed the advances on the role of the PD-1 and CTLA-4 in hematological malignancies,including their functions on mediating T cell-immune tolerance and the progression of targeted immunotherapy,to provide the new strategy for hematological malignancies.
