Relationship of Bilirubin with Acute Ischemic Stroke and Chinese Ischemic Stroke Subclassification
10.3969/j.issn.1006-9771.2015.11.005
- VernacularTitle:胆红素水平与急性缺血性脑卒中及其亚型的相关性
- Author:
Ting TIAN
;
Jing LI
;
Zhenghong SHI
;
Zhiyuan GUAN
;
Bin FENG
- Publication Type:Journal Article
- Keywords:
ischemic stroke;
Chinese ischemic stroke subclassification;
bilirubin;
National Institute of Health Stroke Scale
- From:
Chinese Journal of Rehabilitation Theory and Practice
2015;(11):1260-1263
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship of the serum bilirubin level with acute ischemic stroke (AIS), and Chinese isch-emic stroke subclassification (CISS), stroke severity and short-term outcome of AIS patients. Methods 616 patients with AIS as well as 664 patients without stroke matched with gender and age were compared and analyzed with the non-conditional Logistic regression. The AIS pa-tients were divided based on the CISS, and their bilirubin levels were compared. The AIS patients were divided into high bilirubin group and normal bilirubin group, their scores of the National Institute of Health Stroke Scale (NIHSS) as admission and discharge, and neural func-tion improvement rate were compared. Results The levels of total bilirubin (TBIL), direct bilirubin (DBIL) and indirect bilirubin (IBIL) were higher in the AIS group than in the control group (P<0.01), and the TBIL was the independent risk factors of AIS (OR=1.026, 95%CI 1.012-1.041, P<0.001). There was no significant difference of the levels of TBIL, DBIL and IBIL among the patients of CISS (P>0.05). The NIHSS score was higher in the high bilirubin group than in the normal bilirubin group as admission (P<0.05), but it was not significant as discharge (P>0.05), nor the rate of neural function improvement (P>0.05). Conclusion The serum bilirubin level elevated and correlated with the severity in the AIS patients, which might be the risk of pathogenesis and AIS. The bilirubin was not various with the CISS, and might be less involved in the short-term outcome of AIS.
