Quercetin-loaded PEG-PE micelles reverse drug resistance of MCF-7 ADRr human breast cancer cells
- VernacularTitle:载有槲皮素的PEG-PE胶束对乳腺癌细胞耐药性的逆转效应
- Author:
Jinhua WU
;
Jinhong DUAN
;
Haiyan XU
;
Xianda YANG
- Publication Type:Journal Article
- Keywords:
PEG-PE;
micelles;
quercetin;
MCF-7 ADRr cells
- From:
Basic & Clinical Medicine
2015;(2):174-177
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore whether quercetin-loaded PEG-PE micelles(M-Q) can synergize the growth-in-hibitory activity of adriamycin prepared ( ADR) by reversing the drug resistance of MCF-7 ADRr breast cancer cells in vitro.Methods M-Q was prepared by adding saline to lipid film containing quercetin and PEG-PE.The size of M-Q was characterized by dynamic light scattering ( DLS) .The inhibition of MCF-7 ADRr cells was evaluated by MTS assay after incubation with M-Q and ADR.Results The incorporation efficiency of quercetin by the micelles was above 74%.The average size of M-Q was 11.11 nm.Compared with the quercetin dissolved in ethanol , M-Q more effectively reversed the drug resistance of MCF-7 ADRr cells in vitro.Conclusions PEG-PE micelles may potentially deliver quercetin to cancer cells for reversal of drug resistance .
