Progress on diabetic cognitive dysfunction
- VernacularTitle:糖尿病性认知功能障碍研究进展
- Author:
Meng WANG
;
Wenjun JI
;
Lina CHEN
- Publication Type:Journal Article
- Keywords:
type 2 diabetes mellitus;
Alzheimer's disease;
insulin resistance;
cognitive dysfunction
- From:
Basic & Clinical Medicine
2015;(2):240-243
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic cognitive dysfunction is one of the important complications of diabetes mellitus .Insulin plays an important protective role in cognitive function through MAPK and PI 3-K/Akt signaling pathway .Insulin resistance may give rise to excessive tau protein phosphorylation , formation of neurofibrillary tangles inhibits insulin degrading enzyme , reduces the degradation of amyloid β;enhances oxidative stress , further damages the integrity of the neu-ronal structure and function and eventually leads to cognitive dysfunction .
